The Epstein - Barr Virus BamHI C Promoter Is Not Essential For B Cell 4 Immortalization In Vitro But Greatly Enhances B Cell Growth Transformation
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1 2 3 The Epstein-Barr Virus BamHI C Promoter Is Not Essential For B Cell 4 Immortalization In Vitro But Greatly Enhances B Cell Growth Transformation 5 6 7 Rosemary J. Tierney # , Jasdeep Nagra, Martin Rowe, Andrew I. Bell and Alan B. Rickinson 8 9 School of Cancer Sciences, College of Medical and Dental Sciences, University of 10 Birmingham, Birmingham, United Kingdom. 11 12 Running Title: Role of EBV Cp in EBV-induced B cell transformation 13 14
منابع مشابه
The Epstein-Barr virus BamHI C promoter is not essential for B cell immortalization in vitro, but it greatly enhances B cell growth transformation.
UNLABELLED Epstein-Barr virus (EBV) infection of B cells leads to the sequential activation of two viral promoters, Wp and Cp, resulting in the expression of six EBV nuclear antigens (EBNAs) and the viral Bcl2 homologue BHRF1. The viral transactivator EBNA2 is required for this switch from Wp to Cp usage during the initial stages of infection. EBNA2-dependent Cp transcription is mediated by the...
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EBV-carrying human cell lines, depending on whether the cells are derived from Burkitt's lymphoma (BL) tumor biopsies or transformed by EBV in vitro, have different growth properties in vitro. In contrast, there are no clear differences between tamarin tumor lines and tamarin LCLs in vitro. Both types of tamarin cell lines could grow in agarose and formed colonies unlike human LCLs, althoug...
متن کاملCharacterization of the deletion and rearrangement in the BamHI C region of the X50-7 Epstein-Barr virus genome, a mutant viral strain which exhibits constitutive BamHI W promoter activity.
Epstein-Barr virus infection of peripheral B lymphocytes predominantly results in a latent infection, with a concomitant growth transformation of the infected cells. These cells express six nuclear antigens (EBNAs) and three membrane antigens. Transcription of all the EBNA genes is driven by one of two promoters, Cp or Wp, located near the left end of the viral genome, and the activities of the...
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Background: Immunophenotyping in the rare group of nodal Peripheral T-cell Lymphomas (PTCL) exposes interesting features such as T-cell marker downregulation and paradoxically, the presence of reactive, clustered large-sized CD20 positive B-cells (B-cell proliferation). Epstein-Barr virus (EBV) has been suggested as a putative etiology in pathogenesis of B-cell lymphoma. We aimed to review the ...
متن کاملThe activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factors.
The programme of Epstein-Barr virus (EBV) gene expression that leads to virus-induced growth transformation of resting B lymphocytes is initiated through activation of the BamHI W promoter, Wp. The factors regulating Wp, and the basis of its preferential activity in B cells, remain poorly understood. Previous work has identified a B cell-specific enhancer region which is critical for Wp functio...
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تاریخ انتشار 2014